| | | Monday, March 21st, 2016 | | Placed LF Jim Armstrong on the 15-day disabled list. |
| Monday, February 8th, 2016 | | SP Arthur McKay was designated for assignment, placed on waivers and taken off the 40-man roster. |
| Saturday, February 6th, 2016 | | Signed free agent 1B Wilbert Nance to a 1-year contract worth a total of $1,980,000. |
| Wednesday, February 3rd, 2016 | | Signed Scouting Director Jeff Brown to a 3-year contract extension. |
| Monday, December 28th, 2015 | | Placed MR Carlos Pérez on the active roster. | | Activated MR Carlos Pérez from the 60-day disabled list. |
| Monday, December 21st, 2015 | | Placed MR Christian Cole on the active roster. |
| Tuesday, December 15th, 2015 | | Signed free agent MR Christian Cole to a 3-year contract worth a total of $20,180,000. |
| Monday, December 7th, 2015 | | Placed C José Rodríguez on the active roster. |
| Friday, November 27th, 2015 | | Signed free agent C José Rodríguez to a 2-year contract worth a total of $3,820,000. |
| Tuesday, November 17th, 2015 | | MR Yoshifumi Nakashima received a 1-year contract through automatic renewal worth a total of $400,000. | | CL José Ramos received a 1-year contract through automatic renewal worth a total of $400,000. | | RF Javier Ferra received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Luis Silva received a 1-year contract through automatic renewal worth a total of $400,000. | | RF Víctor Figueroa received a 1-year contract through automatic renewal worth a total of $400,000. | | C Enrique Chávez received a 1-year contract through automatic renewal worth a total of $400,000. | | 1B Wilbert Nance becomes a free-agent. | | 3B Hunter Tosh becomes a free-agent. | | SP J.J. McOran received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Justin Monroe becomes a free-agent. | | SP Lynn Harrison received a 1-year contract through automatic renewal worth a total of $400,000. | | RF Víctor Peezer received a 1-year contract through automatic renewal worth a total of $400,000. | | Activated SP Lynn Harrison from the 60-day disabled list. | | Recalled C Jason Mahoney from Triple A Paradise. | | Recalled 2B Samuel Patel from Triple A Paradise. | | Recalled 1B Paco Hernández from Triple A Paradise. | | Recalled SS Marvin Hoyles from Triple A Paradise. | | Recalled RF Tomás Ramírez from Triple A Paradise. | | Recalled 1B Robert Lyons from Triple A Paradise. | | Recalled CF Alfredo Morales from Double A Saint Paul. | | Recalled 1B Bill Reed from Triple A Paradise. | | Recalled SP Jin-soo Somun from Triple A Paradise. | | Recalled CF Kichisaburo Chikafuji from Triple A Paradise. | | Recalled LF Michael Dunlap from Triple A Paradise. | | Recalled SP Enrique Camacho from Triple A Paradise. | | Recalled SS Christian Harris from Double A Saint Paul. | | Recalled SP Arthur McKay from Triple A Paradise. | | Recalled SP Ron McCarthy from Double A Saint Paul. |
| Saturday, November 14th, 2015 | | SP Domingo Castaneda received a 1-year contract through arbitration worth a total of $4,491,500. | | SP José Flores received a 1-year contract through arbitration worth a total of $1,665,000. | | LF Jim Armstrong received a 1-year contract through arbitration worth a total of $2,061,000. | | CL Jeff Stapp received a 1-year contract through arbitration worth a total of $600,000. | | 2B Sergio Apodaca received a 1-year contract through arbitration worth a total of $611,000. | | SP Greg Dixon received a 1-year contract through arbitration worth a total of $6,504,000. | | MR Si-hun Kim received a 1-year contract through arbitration worth a total of $600,000. | | C Zhao-dao Gong becomes a free-agent. | | MR Fernando Méndez received a 1-year contract through arbitration worth a total of $1,827,000. | | 2B Pablo López becomes a free-agent. | | MR Carlos Pérez received a 1-year contract through arbitration worth a total of $600,000. | | 3B Dan Osborne received a 1-year contract through arbitration worth a total of $2,600,000. |
| Sunday, November 1st, 2015 | | Signed scouting director Jeff Brown to a 5-year, $270,000 per year contract. |
| Saturday, October 24th, 2015 | | Scouting Director Carl Peterson leaves the team, his contract was not renewed. |
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