| | | Thursday, April 21st, 2016 | | Signed free agent SP Lorenzo Torres to a 1-year contract worth a total of $820,000. | | Signed free agent LF Dave Martin to a minor league contract. |
| Thursday, April 14th, 2016 | | Signed free agent MR Billy Young to a minor league contract. | | Signed free agent 3B Manny Cervantes to a minor league contract. |
| Wednesday, April 6th, 2016 | | Placed 2B César Rosales on the 15-day disabled list. |
| Monday, March 7th, 2016 | | Placed SS Ron Robinson on the 60-day disabled list. |
| Tuesday, February 16th, 2016 | | Signed free agent SP Claudio González to a minor league contract. |
| Saturday, February 13th, 2016 | | Signed CL Brian Wilson to a minor league contract extension. | | Signed SP Harry Jones to a minor league contract extension. | | Signed free agent SP Ernesto Canseco to a minor league contract. | | Signed free agent CL Hua-ding Huang to a minor league contract. | | Signed SP Iyasu Zuri to a minor league contract extension. | | Signed free agent RF Joe Stanley to a minor league contract. |
| Friday, February 12th, 2016 | | Signed SP José Aguilera to a minor league contract extension. |
| Thursday, January 21st, 2016 | | Signed free agent 1B Jordan Rivard to a minor league contract. |
| Tuesday, January 19th, 2016 | | Signed free agent 1B Ramiro Muńóz to a 1-year contract worth a total of $420,000. |
| Monday, January 18th, 2016 | | Signed free agent CF Wesley Whitford to a minor league contract. |
| Sunday, January 17th, 2016 | | Signed free agent 1B Ogai Abe to a minor league contract. |
| Saturday, January 2nd, 2016 | | Signed free agent MR George Embree to a 1-year contract worth a total of $400,000. |
| Saturday, December 26th, 2015 | | Signed C Pat Baker to a minor league contract extension. |
| Friday, December 25th, 2015 | | Signed free agent SP Ron Morrow to a minor league contract. |
| Thursday, December 24th, 2015 | | Signed free agent SP Jared Gunther to a minor league contract. |
| Tuesday, December 22nd, 2015 | | Signed free agent SS Joe Crum to a minor league contract. |
| Monday, December 21st, 2015 | | Placed SP Jack Jones on the 40-man roster. | | Placed SP Jack Jones on the active roster. |
| Thursday, December 17th, 2015 | | Signed free agent MR Víctor Rocha to a minor league contract. |
| Tuesday, December 8th, 2015 | | Signed free agent MR Tom Stone to a 1-year contract worth a total of $550,000. |
| Monday, December 7th, 2015 | | Signed free agent LF Leon Winston to a minor league contract. | | Signed free agent 3B Aurelio Cavazos to a minor league contract. |
| Saturday, November 28th, 2015 | | Signed free agent SP Bernard Boyd to a minor league contract. |
| Friday, November 27th, 2015 | | Signed free agent 3B Curtis Kelly to a minor league contract. |
| Wednesday, November 25th, 2015 | | Signed free agent CL Brian Wilson to a minor league contract. |
| Tuesday, November 17th, 2015 | | 2B Tokuma Jozume becomes a free-agent. | | 2B Jason Hubbard received a 1-year contract through automatic renewal worth a total of $400,000. | | C António Rosado received a 1-year contract through automatic renewal worth a total of $400,000. | | 3B Julián Gallegos becomes a free-agent. | | LF Dave Watkins received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Juan Martínez received a 1-year contract through automatic renewal worth a total of $5,000,000. | | LF Felipe Silva becomes a free-agent. | | CF Félix Medina becomes a free-agent. | | SP Earl Phelps becomes a free-agent. | | 2B Diego Hernández received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Norberto Gaona received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Luis Aguilar received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Masao Fujimoto received a 1-year contract through automatic renewal worth a total of $400,000. | | LF Guillermo Chávez received a 1-year contract through automatic renewal worth a total of $400,000. | | CF Rafael Gavcia received a 1-year contract through automatic renewal worth a total of $400,000. | | MR Belarmino Martens received a 1-year contract through automatic renewal worth a total of $400,000. | | C Don Pearce received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Jim Mooney received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Yi-lin Kum received a 1-year contract through automatic renewal worth a total of $400,000. | | 2B César Rosales received a 1-year contract through automatic renewal worth a total of $400,000. | | LF Gustavo Ortega received a 1-year contract through automatic renewal worth a total of $400,000. | | SP Rob Bradley becomes a free-agent. | | SP Greg Eldridge becomes a free-agent. | | SP Salvador Trujillo becomes a free-agent. | | MR Kevin Owens becomes a free-agent. | | MR Tokuma Tanaka becomes a free-agent. | | MR Steve Washington becomes a free-agent. | | MR José Ortíz becomes a free-agent. | | C Carl Thomas becomes a free-agent. | | LF Denis Hawkins becomes a free-agent. | | MR Paco Vega becomes a free-agent. | | SP Glenn Sweeney becomes a free-agent. | | SP Roger Antle becomes a free-agent. | | MR Eduardo Loera becomes a free-agent. | | MR Razan Rin becomes a free-agent. | | MR Marcello Calandrini becomes a free-agent. | | 3B Aurelio Cavazos becomes a free-agent. | | Signed scouting director José Muńóz to a 5-year, $330,000 per year contract. |
| Monday, November 16th, 2015 | | Signed MR Dominic Bell to a minor league contract extension. |
| Sunday, November 15th, 2015 | | Signed SP Júlio Aguilar to a minor league contract extension. | | Signed SP Conan Bird to a minor league contract extension. |
| Friday, November 13th, 2015 | | Signed SP Harry Jones to a minor league contract extension. | | Signed MR David Jiménez to a minor league contract extension. |
| Thursday, November 5th, 2015 | | Signed MR Pedro Trinidad to a 3-year contract extension worth a total of $1,980,000. |
| Sunday, November 1st, 2015 | | Signed free agent MR Yuda Ngilu to a minor league contract. |
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